Prostaglandin D2 receptor 2 (PTGDR2) antibody (BM16)

Prostaglandin D2 receptor 2
Chemoattractant receptor-homologous molecule expressed on Th2 cells
G-protein coupled receptor 44
Gene name: PTGDR2, CRTH2, DL1R, GPR44
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CD294 (prostaglandin D2 receptor 2) is a G-protein-coupled receptor that is preferentially expressed in CD4+ effector T helper 2 (Th2) cells, but also on eosinophils and basophils. It mediates the pro-inflammatory chemotaxis of eosinophils, basophils, and Th2 lymphocytes generated during allergic inflammation. Single nucleotide polymorphisms in the 3' UTR of CD294 gene have been associated with asthma susceptibility. Outside the immune system CD294 is expressed e.g. in gut, heart, and brain. The intracellular C terminal tail contains sites for phosphorylation by protein kinase C.
More Information
ID Covalab mab21339
Product type Primary antibodies
Clonality Monoclonal antibody
Clone BM16
Isotype IgG2a
Raised in Rat
Immunogen The rat monoclonal antibody BM16 recognizes an extracellular epitope of CD294 / CRTH2 (prostaglandin D2 receptor 2), a G-protein-coupled seven-transmembrane protein expressed on Th2 cells, peripheral blood basophils and eosinophils.
Species Hu
Labelling None
Form Purified (protein G)
Preservative NaN3 15 mM
Storage instructions Store at 2-8°C. Do not freeze.
Target CD294
Uniprot ID Q9Y5Y4
Gene ID 11251
Applications FC
Working dilutions Optimal dilution should be determined by the end user.
The following are guidelines only :
FC (1-4 µg/ml)
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