CD1d belongs to CD1 family of transmembrane glycoproteins, associated with beta2 microglobulin, similarly to MHC I molecules. Unlike other CD1 family members, however, CD1d can be also expressed in a non-glycosylated form, which is not associated with beta2 microglobulin. Hence it is not certain how much CD1d plays a role in the presentation of microbial lipid antigens during infection. On the other hand, it is expressed on various antigen presenting cell types. Besides it, CD1d+ thymocytes are involved in the positive selection of sublineage of NKT cells.
|Product type||Primary antibodies|
|Immunogen||The mouse monoclonal antibody 51.1 recognizes an extracellular epitope of CD1d, a 38 kDa transmembrane glycoprotein expressed mainly on cortical thymocytes, marginal zone B cells and other antigen presenting cells, but also i e.g. hepatitis C virus-infected livers.|
|Form||Purified (protein A)|
|Preservative||NaN3 15 mM|
|Storage instructions||Store at 2-8°C. Do not freeze.|
|Applications||FC, IHC-F, IP, WB|
|Working dilutions||Optimal dilution should be determined by the end user.
The following are guidelines only :
FC (4-8 µg/ml)
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