CD49f (alpha 6 integrin) is a type I transmembrane glycoprotein, which noncovalently associates with CD29 (beta 1 integrin) to form VLA-6, and with CD104 (beta 4 integrin) to form alpha6/beta4 integrin complex. CD49f is expressed on platelets, megakaryocytes, monocytes, T cells and thymocytes. It is widely expressed on many cultured adherent cell lines and on epithelia in non-lymphoid tissues. It is important for adhesion to laminins, invasin, and merosin, hence also for cell migration, embryogenesis, metastasis, formation of hemidesmosomes in epithelia, and other processes.
|Product type||Primary antibodies|
|Immunogen||The rat monoclonal antibody GoH3 recognizes an extracellular epitope of CD49f, an alpha6 integrin subunit.|
|Species||Cat, Cow, Dog, Hs, Hu, Mk, Ms, Pig, Rb, Shp|
|Form||Purified (protein G)|
|Preservative||NaN3 15 mM|
|Storage instructions||Store at 2-8°C. Do not freeze.|
|Applications||FC, ICC, IHC-F, IP|
|Working dilutions||Optimal dilution should be determined by the end user.
The following are guidelines only :
FC (1-4 µg/ml)
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