Leukemia inhibitory factor receptor (LIFR) antibody (12D3)

Leukemia inhibitory factor receptor (LIF receptor, LIF-R)
Gene name: LIFR
As low as €337.00
In stock
CD118 (LIFR alpha) is a type I transmembrane glycoprotein of the cytokine receptor family, which associates noncovalently with CD130 to form the functional high affinity LIF receptor, which also acts as an oncostatin M receptor. CD118 alone binds LIF with low affinity. A secreted form of CD118 results from alternative splicing, and may have inhibitory effect, as it also binds LIF, although with low affinity. CD118 is not expressed on lymphocytes, but it is widely expressed outside the immune system. Soluble CD118 level rises during pregnancy, in parallel with a drop in circulating LIF levels.
More Information
ID Covalab mab21337
Product type Primary antibodies
Clonality Monoclonal antibody
Clone 12D3
Isotype IgG1 kappa
Raised in Mouse
Immunogen The mouse monoclonal antibody 12D3 recognizes an extracellular epitope of CD118, a transmembrane glycoprotein, which associates with CD130 to form the functional high affinity LIF receptor.
Species Hu
Labelling None
Form Purified (protein A)
Preservative NaN3 15 mM
Storage instructions Store at 2-8°C. Do not freeze.
Target LIFR
Uniprot ID P42702
Gene ID 3977
Applications ELISA, FC, WB
Working dilutions Optimal dilution should be determined by the end user.
The following are guidelines only :
FC (2-5 µg/ml)
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