CD74 antibody (LN2)

HLA class II histocompatibility antigen gamma chain
HLA-DR antigens-associated invariant chain
Ia antigen-associated invariant chain (Ii)
Gene name: CD74, DHLAG
As low as €370.70
In stock
CD74 (the MHC II-associated invariant chain, Ii) is a type II transmembrane protein expressed in antigen-presenting cells, that serves as MHC II chaperone which promotes MHC II trafficking from the ER to endocytic compartments, prevents peptide binding in the ER and contributes to peptide editing in the MHC II compartment; it is also an accessory signaling molecule implicated e.g. in malignant B cell proliferation. Stimulation of cell surface CD74 leads to NFkappaB activation, which enables entry of the stimulated cell into the S phase. CD74 binds pro-inflammatory cytokine MIF with high affinity and interacts with CD44. Binding of Vpu, an HIV1 protein, to CD74 modulates MHC II presentation.
More Information
ID Covalab mab21335
Product type Primary antibodies
Clonality Monoclonal antibody
Clone LN2
Isotype IgG1
Raised in Mouse
Immunogen The antibody LN2 recognizes an extracellular epitope of CD74 (the MHC II-associated invariant chain, Ii), a type II transmembrane protein expressed in antigen-presenting cells, as well as e.g. on activated neoplastic cells in T cell lymphomas, in lymph node germinal center, mantle zone B cells, histiocytes, interdigitating reticulum cells, Langerhans cells, thymic dendritic cells and peripheral blood B lymphocytes.
Species Hu
Labelling None
Form Purified (protein A)
Preservative NaN3 15 mM
Storage instructions Store at 2-8°C. Do not freeze.
Target CD74
Uniprot ID P04233
Gene ID 972
Applications FC, ICC, IHC-P, IP, WB
Working dilutions Optimal dilution should be determined by the end user.
The following are guidelines only :
FC (2-5 µg/ml)
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