Granzyme A antibody (CB9)

Granzyme A
CTL tryptase
Cytotoxic T-lymphocyte proteinase 1
Fragmentin-1
Granzyme-1
Hanukkah factor (H factor, HF)
Gene name: GZMA, CTLA3, HFSP
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Granzyme A is a serine protease expressed in the cytoplasmic granules of T cells and NK cells. Vectorial secretion of perforin and granzymes is responsible for their granule-mediated cytotoxicity. Similarly to granzyme B, granzyme A acts to destroy the target cells by proteolysis of their particular components. In case of granzyme A the targets are e.g. APEX1 (it destroys its oxidative repair activity), and nucleosome assembly protein SET (it disrupts its nucleosome assembly activity and allows the SET complex to translocate into the nucleus to nick and degrade the DNA).
More Information
ID Covalab mab21328
Product type Primary antibodies
Clonality Monoclonal antibody
Clone CB9
Isotype IgG1 kappa
Raised in Mouse
Immunogen The mouse monoclonal CB9 recognizes granzyme A, a 28 kDa serine protease expressed intracellularly in activated Tc cells and NK cells.
Species Hu
Labelling None
Form Purified (protein A)
Preservative NaN3 15 mM
Storage instructions Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on the label.
Target Granzyme A
Uniprot ID P12544
Gene ID 3001
Applications FC, ICC, IP
Working dilutions Optimal dilution should be determined by the end user.
The following are guidelines only :
FC (5-10 µg/ml)
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