CD272, a type I transmembrane glycoprotein, contains in its intracellular domain two ITIM sequences, which are upon CD272 triggering phosphorylated and recruit SHP phosphatases to attenuate cell activation. CD272 is expressed on B and T lymphocytes, NK cells, dendritic cells, and macrophages, and its ligand is CD270. Defects in CD272-CD270 inhibitory mechanism lead to autoimmune diseases. Overexpression of CD272 is a marker of tolerant T cells.
|Product type||Primary antibodies|
|Immunogen||The mouse monoclonal antibody MIH26 recognizes an extracellular epitope of CD272, a transmembrane glycoprotein serving as a negative regulator of the activation in various leukocyte types.|
|Form||Purified (protein A)|
|Preservative||NaN3 15 mM|
|Storage instructions||Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on the label.|
|Working dilutions||Optimal dilution should be determined by the end user.
FC (2-5 µg/ml)
Write Your Own Review