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SIGLEC8 antibody (7C9)
Sialic acid-binding Ig-like lectin 8 (Siglec-8)
Sialoadhesin family member 2 (SAF-2)
Gene name: SIGLEC8
Sialoadhesin family member 2 (SAF-2)
Gene name: SIGLEC8
As low as
€407.80
In stock
Ref
00118878
SIGLEC8 is a sialic acid binding lectin similar to CD33. In its cytoplasmic comain it contains an immunoreceptor tyrosine-based inhibitory motif (ITIM), and a motive similar to a binding site for SLAM-associated protein. SIGLEC8 is expressed e.g. in lymph nodes and spleen. It is an eosinophil marker, although it can be found also on the surface of mast cells. Crosslinking of SIGLEC8 leads to apoptosis. Soluble form of SIGLEC8 can be foud in human serum, especially in case of eosinophil-associated diseases.
| ID Covalab | mab21310 |
|---|---|
| Product type | Primary antibodies |
| Clonality | Monoclonal antibody |
| Clone | 7C9 |
| Isotype | IgG1 |
| Raised in | Mouse |
| Immunogen | The mouse monoclonal antibody 7C9 recognizes an extracellular epitope of SIGLEC8, an eosinophil marker, expressed e.g. in lymph nodes and spleen. |
| Activity cross reaction | Extracellular domain of human SIGLEC8 fused with Fc fragment of human IgG1 |
| Species | Hu |
| Labelling | None |
| Form | Purified (protein A) |
| Preservative | NaN3 15 mM |
| Storage instructions | Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on the label. |
| Target | SIGLEC8 |
| Uniprot ID | Q9NYZ4 |
| Gene ID | 27181 |
| Applications | ELISA, FC, IP |
| Working dilutions | Optimal dilution should be determined by the end user. |
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