c-Myc antibody (9E10)

Myc proto-oncogene protein
Class E basic helix-loop-helix protein 39
Transcription factor p64
Gene name: MYC, BHLHE39
As low as €480.40
In stock
The c-Myc protein is a transcription factor, which is encoded by the c-Myc gene on human chromosome 8q24. c-Myc is commonly activated in a variety of tumor cells and plays an important role in cellular proliferation, differentiation, apoptosis and cell cycle progression. The phosphorylation of c-Myc has been investigated and previous studies have suggested a functional association between phosphorylation at Thr58/Ser62 by glycogen synthase kinase 3, cyclin dependent kinase, ERK2 and C-Jun N terminal Kinase (JNK) in cell proliferation and cell cycle regulation. Studies also have shown that c-Myc is essential for tumor cell development in vasculogenesis and angiogenesis that distribute blood throughout the cells, and which brought extensive attention in the development of new therapeutic approach for cancer treatment.
More Information
ID Covalab mab50730
Product type Primary antibodies, Tags
Clonality Monoclonal antibody
Clone 9E10
Isotype IgG1 / Kappa
Raised in Mouse
Immunogen Synthetic peptide CT32 (myc) sequence: AEEQKLISEEDLLRKRREQLKHKLEQLRNSCA
Activity cross reaction Reacts with human, mouse and Drosophila MYC protein. Not tested in other species. Recognizes the c-myc peptide in random coil configuration, not as a helix. Does not react with V-myc.
Species D. mel., Hu, Ms
Form Purified
Preservative NaN3 0.05%
Storage instructions Short term storage at +4°C.
For extended periods store in aliquots at -20°C.
Antibodies are guaranteed for 6 month from date of receipt.
Target Proto-oncogene c-Myc
Uniprot ID P01106
Applications ELISA, FC, ICC, IF, IHC, IHC - F, IHC - P, IP, WB
Working dilutions Optimal dilution should be determined by the end user.
The following are guidelines only :
- FC: 1/50 to 1/200
- ICC : 1/50 to 1/200
- IF : 1/50 to 1/200
- IHC, IP, WB and ELISA : use at assay dependent dilµtion
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