Ambra1 antibody

Activating molecule in BECN1-regulated autophagy protein 1
autophagy/beclin 1 regulator 1
Gene name: Ambra1, Kiaa1736
As low as €278.30
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00013214
Regulates autophagy and development of the nervous system. Involved in autophagy in controlling protein turnover during neuronal development, and in regulating normal cell survival and proliferation
More Information
ID Covalab pab0224
Product type Primary antibodies
Clonality Polyclonal antibody
Raised in Rabbit
Immunogen Synthetic peptide derived from N-term domain of the mouse Ambra 1 protein.
Activity cross reaction Reacts with mouse 120 kDa Ambra1 protein. Cross reacts with human and rat protein.
Species Hu, Ms, Rat
Labelling None
Form Antiserum
Preservative None
Storage instructions Lyophilized powder stable for a minimum of 2 years at -20°C.
Store reconstituted antibodies at +4°C.
For extended periods store in aliquots at -20°C.
Antibodies are guaranteed for 6 month from date of receipt.
Target Activating molecule in BECN1-regulated autophagy protein 1 (Ambra1)
Uniprot ID Q9C0C7
Gene ID 55626
Applications ELISA, EM, IF, IHC, WB
Working dilutions Optimal dilution should be determined by the end user.
Publication * Manganelli V et al. The Role of Cardiolipin as a Scaffold Mitochondrial Phospholipid in Autophagosome Formation: In Vitro Evidence, Biomolecules, Feb 2021
* Manganelli V et al. Raft-like lipid microdomains drive autophagy initiation via AMBRA1-ERLIN1 molecular association within MAMs. Autophagy. 2020 Oct 9.
* AS Puebla, Lysosome-dependent cell death: molecular players and implications for disease, PhD thesis in biology, director P Boya, University Complutense of Madrid, 2019 (IF, Ms)
* Rodríguez-Muela N et al. Cell Death Differ. 2015 Mar,22(3):476-87.(IHC-F, Ms)
* Pagliarini V et al. Cell Death Differ. 2012 Sep,19(9):1495-504. (WB, Hu)
* Paronetto M.P et al. Peptidic and peptidomimetic compound for regulating autophagy. US Patent Application. 2011 Nov : 20110281804.
* Armstrong J.L. et al. Clin Cancer Res. 2011 Apr 15,17(8):2216-26.(WB, Hu)
* Di Bartolomeo S.et al. J Cell Biol. 2010 Oct 4,191(1):155-68.(IF, EM, Hu)
* Fimia G.M. et al. Nature. 2007 Jun 28,447(7148):1121-5.
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