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Histone H3 citrulline R2 + R8 + R17 antibody (7C10)
Histone H3.3C
Gene name: H3F3C
Gene name: H3F3C
As low as
€278.30
In stock
Ref
00012694
Histone H3 is citrullinated by PADI4 this modification induce a repression of transcription and impairs the methylation.
| ID Covalab | mab0072-P |
|---|---|
| Product type | Primary antibodies |
| Clonality | Monoclonal antibody |
| Clone | 7C10 |
| Isotype | IgG1 / Kappa |
| Raised in | Mouse |
| Immunogen | Synthetic peptide derived from Nter domain of human Histone H3 containing Citrulline at position 2-8-17 |
| Activity cross reaction | Reacts with human Histone H3 Citrulline at the 3 positions: 2, 8 and 17. No cross reaction with mono or bis H3-Cit. Not tested in other species. May cross reacts with other species due to sequence homology. |
| Species | Hu |
| Labelling | None |
| Form | Purified (protein A) |
| Preservative | None |
| Storage instructions | Lyophilized powder stable for a minimum of 2 years at -20°C. Store reconstituted antibodies at +4°C. For extended periods store in aliquots at -20°C. Antibodies are guaranteed for 6 month from date of receipt. |
| Target | Histone H3 citrulline R2 + R8 + R17 |
| Uniprot ID | Q6NXT2 |
| Applications | ELISA, FC, ICC, IF |
| Working dilutions | Optimal dilution should be determined by the end user. The following are guidelines only : ELISA 1:20 000 - 1:100 000 ICC/ IF 1:100 - 1:500 |
| Publication | * Pircher J et al. Nat Commun. 2018 Apr 18,9(1):1523. (IF) |
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