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SDHB antibody
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
Iron-sulfur subunit of complex II (Ip)
Gene name: SDHB, SDH, SDH1
Iron-sulfur subunit of complex II (Ip)
Gene name: SDHB, SDH, SDH1
As low as
€480.40
In stock
Ref
00096265
Part of the succinate dehydrogenase complex, SDHB is a mitochondrial protein that interfaces with the catalysis of succinate dehydrogenase. In many gastrointestinal tumors, SDHB is irregularly expressed, and leads to mutational activation of KIT. This may be as a result of elevated oxidative stress caused by mitochondrial dysfunction. In Dutch populations, there is a higher prevalence of mutations in the SDHB gene, and a higher overall level of hereditary paraganglioma and pheochromocytoma syndromes than in other Europeans. Similar trends in mutations in this gene seem to be related to atherosclerosis in American populations. Overall, the SDHB protein effects multiple cellular metabolism processes and it is not surprisingly linked to metabolism-related cellular dysfunctions.
| ID Covalab | pab52799 |
|---|---|
| Product type | Primary antibodies |
| Clonality | Polyclonal antibody |
| Raised in | Rabbit |
| Immunogen | A genomic peptide made to an N-terminal region of the human SDHB protein (within residues 1-150). |
| Activity cross reaction | Reacts with human and mouse SDHB. May cross react with Rat, Bovine, Porcine (92%). |
| Species | Hu, Ms |
| Labelling | None |
| Form | Antigen affinity purified |
| Preservative | NaN3 0.05% |
| Storage instructions | Short term storage at +4°C. For extended periods store in aliquots at -20°C. Antibodies are guaranteed for 6 month from date of receipt. |
| Target | SDHB |
| Uniprot ID | P21912 |
| Applications | ICC, IF, IHC - P, WB |
| Working dilutions | Optimal dilution should be determined by the end user. The following are guidelines only : ICC (1:50 - 1:100) IF (1:50 - 1:100) IHC - P (1:50 - 1:100) WB (1:7000) |
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