Hypoxia-inducible factor 2-alpha antibody (ep190b)

Endothelial PAS domain-containing protein 1, EPAS-1
Basic-helix-loop-helix-PAS protein MOP2
Class E basic helix-loop-helix protein 73, bHLHe73
HIF-1-alpha-like factor, HLF
Hypoxia-inducible factor 2-alpha, HIF-2-alpha, HIF2-alpha
Member of PAS protein 2
PAS domain-containing protein 2
Gene name: EPAS1, BHLHE73, HIF2A, MOP2, PASD2
As low as €480.40
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Transcription factor involved in the induction of oxygen regulated genes. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. May also play a role in the formation of the endothelium that gives rise to the blood brain barrier. Potent activator of the Tie-2 tyrosine kinase expression. Activation seems to require recruitment of transcriptional coactivators such as CREBPB and probably EP300. Interaction with redox regulatory protein APEX seems to activate CTAD.
More Information
ID Covalab mab50055
Product type Primary antibodies
Clonality Monoclonal antibody
Clone ep190b
Isotype IgG1
Raised in Mouse
Immunogen Human HIF-2 alpha amino acids 535-631
Activity cross reaction Reacts with HIF-2 alpha from human, mouse hamster and rat. Does not cross-react with HIF-1 alpha.
Species Ham, Hu, Ms, Rat
Labelling None
Form Purified (protein G)
Preservative NaN3 0.1%
Storage instructions Aliquot and store at -20°C or -80°C. Avoid freeze-thaw cycles.
Target Hypoxia-inducible factor 2-alpha
Uniprot ID Q99814
Gene ID 2034
Applications ChIP, ELISA, FC, ICC, IF, IHC, IP, WB
Working dilutions Optimal dilution should be determined by the end user.
The following are guidelines only:
ELISA (1:100-1:2000)
FC (1:400)
IHC (1:150-1:300)
WB (1 - 2 µg/ml)
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