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Meiotic recombination protein Mre11 antibody
Double-strand break repair protein MRE11A
Meiotic recombination 11 homolog 1 (MRE11 homolog 1)
Meiotic recombination 11 homolog A (MRE11 homolog A)
Gene name: MRE11A
Meiotic recombination 11 homolog 1 (MRE11 homolog 1)
Meiotic recombination 11 homolog A (MRE11 homolog A)
Gene name: MRE11A
As low as
€480.40
In stock
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00029050
The hMre11-hRad50-NBS1 protein plays a central role in the human cellular DNA-Damage response, with recent studies indicating that these proteins help link DNA-damage detection to DNA-repair and cell cycle-checkpoint functions.This protein complex has been implicated in the activation of cell cycle-regulatory pathways, due to the fact that the NBS1 gene mutates in the chromosomal-instability syndrome, Nijmegen breakdown syndrome (NBS), which is characterized by increased cancer incidence, cell cycle checkpoint defects, and ionizing radiation sensitivity.
ID Covalab | pab50001 |
---|---|
Product type | Primary antibodies |
Clonality | Polyclonal antibody |
Raised in | Rabbit |
Immunogen | Full length human Mre11 protein. |
Activity cross reaction | Reacts with Mre11 from human, mouse, rat, chicken, hamster |
Species | Chick, Ham, Hu, Ms, Rat |
Labelling | None |
Form | Antiserum |
Preservative | NaN3 |
Storage instructions | Aliquot and store at -20°C or -80°C. Avoid freeze-thaw cycles. |
Target | Meiotic recombination protein Mre11 |
Uniprot ID | P49959 |
Applications | ChIP, FC, ICC, IF, IHC, IP, WB |
Working dilutions | Optimal dilution should be determined by the end user. The following are guidelines only : - IF : 1/200 - IP : 3 µl - WB : 1/5000 - IHC: 1/10 to 1/200 |
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