Meiotic recombination protein Mre11 antibody

Double-strand break repair protein MRE11A
Meiotic recombination 11 homolog 1 (MRE11 homolog 1)
Meiotic recombination 11 homolog A (MRE11 homolog A)
Gene name: MRE11A
As low as €480.40
In stock
The hMre11-hRad50-NBS1 protein plays a central role in the human cellular DNA-Damage response, with recent studies indicating that these proteins help link DNA-damage detection to DNA-repair and cell cycle-checkpoint functions.This protein complex has been implicated in the activation of cell cycle-regulatory pathways, due to the fact that the NBS1 gene mutates in the chromosomal-instability syndrome, Nijmegen breakdown syndrome (NBS), which is characterized by increased cancer incidence, cell cycle checkpoint defects, and ionizing radiation sensitivity.
More Information
ID Covalab pab50001
Product type Primary antibodies
Clonality Polyclonal antibody
Raised in Rabbit
Immunogen Full length human Mre11 protein.
Activity cross reaction Reacts with Mre11 from human, mouse, rat, chicken, hamster
Species Chick, Ham, Hu, Ms, Rat
Labelling None
Form Antiserum
Preservative NaN3
Storage instructions Aliquot and store at -20°C or -80°C. Avoid freeze-thaw cycles.
Target Meiotic recombination protein Mre11
Uniprot ID P49959
Applications ChIP, FC, ICC, IF, IHC, IP, WB
Working dilutions Optimal dilution should be determined by the end user.
The following are guidelines only :
- IF : 1/200
- IP : 3 µl
- WB : 1/5000
- IHC: 1/10 to 1/200
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