Hypoxia inducible factor-1 alpha antibody (ESEE122)

Hypoxia-inducible factor 1-alpha, HIF-1-alpha, HIF1-alpha, HIF-1 α
ARNT-interacting protein
Basic-helix-loop-helix-PAS protein MOP1
Class E basic helix-loop-helix protein 78, bHLHe78
Member of PAS protein 1
PAS domain-containing protein 8
Gene name: HIF1A, BHLHE78, MOP1, PASD8
As low as €480.40
In stock
Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters.
More Information
ID Covalab mab50056
Product type Primary antibodies
Clonality Monoclonal antibody
Clone ESEE122
Isotype IgG1
Raised in Mouse
Immunogen Human HIF-1 alpha amino acids 329-530
Activity cross reaction Reacts with human HIF-1 alpha. Cross reacts with proteins from bovine, mouse and rat.
Species Bov, Ca, Hu, Ms, Rat
Labelling None
Form Purified (protein G)
Preservative NaN3 0.01%
Storage instructions Aliquot and store at -20°C or -80°C. Avoid freeze-thaw cycles.
Target Hypoxia-inducible factor 1-alpha
Uniprot ID Q16665
Gene ID 3091
Applications ICC, IF, IHC, IP, WB
Working dilutions Optimal dilution should be determined by the end user.
The following are guidelines only :
ICC/IF (10 ug/ml)
IHC (1:100-1:5000)
IP (1:10-1:500)
WB (1:500-1:1000)
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