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Histone H3 citrulline R2 + R8 + R17 antibody
Histone H3.3C
Gene name: H3F3C
Gene name: H3F3C
As low as
€278.30
In stock
Ref
00013175
This core component of the nucleosome can be citrullinated on arginines 2, 8 and 17 by PADI4. These modifications blocks methylation and so represses the transcription
| ID Covalab | pab0208 |
|---|---|
| Product type | Primary antibodies |
| Clonality | Polyclonal antibody |
| Raised in | Rabbit |
| Immunogen | Synthetic peptide derived from Nter domain of human Histone H3 containing Citrulline at position 2-8-17 |
| Activity cross reaction | Reacts with human Histone H3 Citrulline at the 3 positions: 2, 8 and 17. Reacts with mono or di H3-Cit. Not tested in other species. May cross reacts with other species due to sequence homology. |
| Species | Hu |
| Labelling | None |
| Form | Antiserum |
| Preservative | None |
| Storage instructions | Lyophilized powder stable for a minimum of 2 years at -20°C. Store reconstituted antibodies at +4°C. For extended periods store in aliquots at -20°C. Antibodies are guaranteed for 6 month from date of receipt. |
| Target | Histone H3 citrulline R2 + R8 + R17 |
| Antibody / Antigen | pep0208 |
| Uniprot ID | Q6NXT2 |
| Gene ID | 440093 |
| Applications | ChIP, ELISA, FC, ICC, IHC, WB |
| Working dilutions | Optimal dilution should be determined by the end user. The following are guidelines only : - IHC : 1/200 to 1/1000 - WB : 1/5 000 to 1/50 000 |
| Publication | Raijmakers R et al. Methylation of arginine residues interferes with citrullination by peptidylarginine deiminases in vitro. J Mol Biol. 2007 Apr 6;367(4):1118-29. |
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