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Hsc70 (Hsp73) (1B5) antibody
Heat shock cognate 71 kDa protein
Heat shock 70 kDa protein 8
Lipopolysaccharide-associated protein 1, LAP-1, LPS-associated protein 1
Gene name: HSPA8, HSC70, HSP73, HSPA10
Heat shock 70 kDa protein 8
Lipopolysaccharide-associated protein 1, LAP-1, LPS-associated protein 1
Gene name: HSPA8, HSC70, HSP73, HSPA10
As low as
€552.20
In stock
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00096748
Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes
ID Covalab | mab60235 |
---|---|
Product type | Primary antibodies |
Clonality | Monoclonal antibody |
Clone | 1B5 |
Isotype | IgG2a |
Raised in | Rat |
Immunogen | Hsc70 purified from sodium arsenite treated heat-resistant variants of Chinese hamster cells. |
Activity cross reaction | Reacts with human Hsc70 (Hsp73). Cross-reacts with mouse, rat, rabbit, guinea pig, hamster, monkey, sheep, chicken, bovine, canine and porcine protein. |
Species | Chick, Hu, Ma, Ms, Rat |
Labelling | None |
Form | Purified (protein G) |
Preservative | None |
Storage instructions | Store frozen product at or below -20°C. Thawed product may be stored for 2-4 weeks at 4°C. For optimal storage, aliquot and store at -20°C. |
Target | Hsc70 (Hsp73) |
Uniprot ID | P11142 |
Gene ID | 3312 |
Applications | ICC, IHC, IP, WB |
Working dilutions | Optimal dilution should be determined by the end user. The following are guidelines only : WB (0.1 µg/ml) IP (5 µg/ml ) IHC (5 µg/ml) ICC ( 5 µg/ml) |
Positive control | HeLa Heat Shocked Cell Lysate |
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