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Retinal-specific ATP-binding cassette transporter (C-terminus) antibody
Retinal-specific ATP-binding cassette transporter
ATP-binding cassette sub-family A member 4
RIM ABC transporter (RIM protein) (RmP)
Stargardt disease protein
Gene name : ABCA4, ABCR
ATP-binding cassette sub-family A member 4
RIM ABC transporter (RIM protein) (RmP)
Stargardt disease protein
Gene name : ABCA4, ABCR
As low as
€294.00
In stock
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00028959
Defects in ABCA4 are the cause of Stargardt disease type 1 (STGD1) .
In the visual cycle, acts as an inward-directed retinoid flipase, retinoid substrates imported by ABCA4 from the extracellular or intradiscal (rod) membrane surfaces to the cytoplasmic membrane surface are all-trans-retinaldehyde (ATR) and N-retinyl-phosphatidyl-ethanolamine (NR-PE). Once transported to the cytoplasmic surface, ATR is reduced to vitamin A by trans-retinol dehydrogenase (tRDH) and then transferred to the retinal pigment epithelium (RPE) where it is converted to 11-cis-retinal. May play a role in photoresponse, removing ATR/NR-PE from the extracellular photoreceptor surfaces during bleach recovery.
In the visual cycle, acts as an inward-directed retinoid flipase, retinoid substrates imported by ABCA4 from the extracellular or intradiscal (rod) membrane surfaces to the cytoplasmic membrane surface are all-trans-retinaldehyde (ATR) and N-retinyl-phosphatidyl-ethanolamine (NR-PE). Once transported to the cytoplasmic surface, ATR is reduced to vitamin A by trans-retinol dehydrogenase (tRDH) and then transferred to the retinal pigment epithelium (RPE) where it is converted to 11-cis-retinal. May play a role in photoresponse, removing ATR/NR-PE from the extracellular photoreceptor surfaces during bleach recovery.
| ID Covalab | pab0888-P |
|---|---|
| Product type | Primary antibodies |
| Clonality | Polyclonal antibody |
| Raised in | Rabbit |
| Immunogen | Synthetic peptide derived from C terminal domain of human ABCA4 protein. |
| Activity cross reaction | Reacts with primate ABCA4 protein: human, mouse, rat, dog, monkeys... |
| Species | Hu, Mk, Ms, Rat |
| Labelling | None |
| Form | Purified (protein A) |
| Preservative | None |
| Storage instructions | Lyophilized powder stable for a minimum of 2 years at -20°C. Store reconstituted antibodies at +4°C. For extended periods store in aliquots at -20°C. Antibodies are guaranteed for 6 month from date of receipt. |
| Target | Retinal-specific ATP-binding cassette transporter |
| Uniprot ID | P78363 |
| Applications | ELISA, IHC, WB |
| Working dilutions | Optimal dilutions should be determined by the end user. The following are guidelines only : - WB : 1 to 5 µg/ml - IHC : 1/100 to 1/1000 |
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