We use cookies to make your experience better. To comply with the new e-Privacy directive, we need to ask for your consent to set the cookies. Learn more.
KEAP1 antibody
Kelch-like ECH-associated protein 1
Cytosolic inhibitor of Nrf2, INrf2
Kelch-like protein 19
Gene name : KEAP1, INRF2, KIAA0132, KLHL19
Cytosolic inhibitor of Nrf2, INrf2
Kelch-like protein 19
Gene name : KEAP1, INRF2, KIAA0132, KLHL19
As low as
€294.00
In stock
Ref
00106879
Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome.
| ID Covalab | pab0973-P |
|---|---|
| Product type | Primary antibodies |
| Clonality | Polyclonal antibody |
| Raised in | Rabbit |
| Immunogen | Synthetic peptide of derived from C terminal part of human KEAP1. |
| Activity cross reaction | Reacts with KEAP1 from human, pig, guinea pig, sheep and other species (due to 100% sequence homology) |
| Species | G pig, Hu, Po |
| Labelling | None |
| Form | Purified (protein A) |
| Preservative | None |
| Storage instructions | Short term storage at +4°C. For extended periods store in aliquots at -20°C. Antibodies are guaranteed for 6 month from date of receipt. |
| Target | KEAP1 |
| Uniprot ID | Q14145 |
| Gene ID | 9817 |
| Applications | ELISA, ICC, IF, WB |
| Working dilutions | Optimal dilutions should be determined by the end user. The following are guidelines only: WB (1:500 - 1:200) ICC/ IF (1:200 - 1:1000) |
Write Your Own Review