KEAP1 antibody

Kelch-like ECH-associated protein 1
Cytosolic inhibitor of Nrf2, INrf2
Kelch-like protein 19
Gene name : KEAP1, INRF2, KIAA0132, KLHL19
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Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome.
More Information
ID Covalab pab0973-P
Product type Primary antibodies
Clonality Polyclonal antibody
Raised in Rabbit
Immunogen Synthetic peptide of derived from C terminal part of human KEAP1.
Activity cross reaction Reacts with KEAP1 from human, pig, guinea pig, sheep and other species (due to 100% sequence homology)
Species G pig, Hu, Po
Labelling None
Form Purified (protein A)
Preservative None
Storage instructions Short term storage at +4°C.
For extended periods store in aliquots at -20°C.
Antibodies are guaranteed for 6 month from date of receipt.
Target KEAP1
Uniprot ID Q14145
Gene ID 9817
Applications ELISA, ICC, IF, WB
Working dilutions Optimal dilutions should be determined by the end user.
The following are guidelines only:
WB (1:500 - 1:200)
ICC/ IF (1:200 - 1:1000)
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