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VPS34 antibody
Phosphatidylinositol 3-kinase catalytic subunit type 3 (PI3-kinase type 3) (PI3K type 3) (PtdIns-3-kinase type 3)
Phosphatidylinositol 3-kinase p100 subunit
Phosphoinositide-3-kinase class 3
hVps34
Gene name: PIK3C3, VPS34
Phosphatidylinositol 3-kinase p100 subunit
Phosphoinositide-3-kinase class 3
hVps34
Gene name: PIK3C3, VPS34
As low as
€480.40
In stock
Ref
00096315
VPS34, also known as phosphoinositide-3-kinase p100 subunit or PIK3C3 (phosphoinositide-3-kinase, class III), is a member of the PI3/PI4-kinase family. It is ubiquitously expressed with predominant expression in skeletal muscle and is believed to participate in endosome to lysosome transport, multivesicular body formation, autophagy and retrograde endosome to Golgi transport. VPS34 is the catalytic subunit of class III PI3Ks and forms a heterodimer with p150, a regulatory subunit of class 3 PI3Ks. It exclusively phosphorylates phosphatidylinositol to produce PtdIns3P. The activity of VPS34 is enhanced by manganese and can be regulated by nutrients, suggesting an important role of VPS34 in the regulation of mTOR protein synthesis. VPS34 also forms a complex with Beclin1 that promotes autophagy and tumor supression.
| ID Covalab | pab50333 |
|---|---|
| Product type | Primary antibodies |
| Clonality | Polyclonal antibody |
| Raised in | Rabbit |
| Immunogen | Synthetic peptide made to an internal portion of the human protein (within residues 700-850) |
| Activity cross reaction | Reacts with human VPS34. Cross reacts with proteins from rat, mouse and porcine. The immunogen sequence has 87% homology with Xenopus protein. Not tested in other species |
| Species | Hu, Ms, Po, Rat |
| Labelling | None |
| Form | Antigen affinity purified |
| Preservative | NaN3 0.05% |
| Storage instructions | Short term storage at +4°C. For extended periods store in aliquots at -20°C. Antibodies are guaranteed for 6 month from date of receipt. |
| Target | VPS34 |
| Uniprot ID | Q8NEB9 |
| Applications | ICC, IF, WB |
| Working dilutions | Optimal dilution should be determined by the end user. The following are guidelines only: - WB : 1/1 000 - ICC/IF: 1/100 |
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