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TCR Cbeta1 antibody (JOVI.1)
T cell receptor beta constant 1 (TRBC1)
Gene name: TRBC1
Gene name: TRBC1
As low as
€407.80
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00118805
Alpha-beta T cell receptors (TCRs) are antigen specific receptors, which are essential to the immune response and are present on the cell surface of T lymphocytes. They recognize peptide-loaded major histocompatibility complexes (pMHCs), that are displayed by antigen presenting cells (APCs). Binding of alpha-beta TCR to pMHC initiates TCR-CD3 clustering on the cell surface and intracellular activation of LCK, that phosphorylates the ITAM motifs of CD3gamma, CD3delta, CD3epsilon and CD3zeta, enabling the recruitment of ZAP70. In turn, ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium signaling, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NFkappaB (NF-kB) pathways, leading to the mobilization of transcription factors, that are critical for gene expression and essential for T cell growth and differentiation. The T cell repertoire is generated by V-D-J-C rearrangements. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MHC restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TCRs with the pMHCs shapes TCR structural and functional avidity.
ID Covalab | mab21306 |
---|---|
Product type | Primary antibodies |
Clonality | Monoclonal antibody |
Clone | JOVI.1 |
Isotype | IgG2a kappa |
Raised in | Mouse |
Immunogen | The mouse monoclonal antibody JOVI.1 recognizes an extracellular epitope on TCR Cbeta1 (TRBC1). |
Activity cross reaction | Thymus, spleen, and mesenteric lymph nodes isolated from a mouse transgenic for human TCR Vbeta3Cbeta1 |
Species | Hu |
Labelling | None |
Form | Purified (protein A) |
Preservative | NaN3 15 mM |
Storage instructions | Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on the label. |
Target | TRBC1 |
Uniprot ID | P01850 |
Gene ID | 28639 |
Applications | FC, IHC - F, IP |
Working dilutions | Optimal dilution should be determined by the end user. |
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