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Epidermal Transglutaminase, activated (TG3) (hu)
Transglutaminase 3 (TG3)
Protein-glutamine gamma-glutamyltransferase E (EC:2.3.2.13)
Transglutaminase E, TG(E), TGE, TGase E
Transglutaminase-3, TGase-3, TG3a
Gene name : TGM3
Protein-glutamine gamma-glutamyltransferase E (EC:2.3.2.13)
Transglutaminase E, TG(E), TGE, TGase E
Transglutaminase-3, TGase-3, TG3a
Gene name : TGM3
As low as
€683.10
In stock
Ref
00109855
Transglutaminase-3 is a calcium dependant enzyme involved in keratinization
| ID Covalab | pro0003 |
|---|---|
| Principe | Active His6-rhTG3 catalyzes acyl-transfer reactions from glutamine residues in proteins or peptides to primary amines, e. g. the formation of ε-(γ-glutamyl)-lysine bonds between proteins by transferring the acyl group of a peptide-bound glutamine residue to the primary amino group of a peptide-bound lysine residue. Active His6-rhTG3 may also be used for immunoprecipitation and the detection of TG3 autoantibodies. |
| Applications | FA, IP |
| Labelling | His-Tag |
| Species | Hu |
| Form | Recombinant |
| Storage instructions | Storage for several months is possible at - 20°C. Avoid repeated freezing and thawing Delivery at ambient temperature is possible |
| Target | Transglutaminase-3 (TGase-3) |
| Uniprot ID | Q08188 |
| Gene ID | 7053 |
| Product type | Proteins |
| Raised in | Insect cells |
| Poids moléculaire | 78 kDa (52kDa + 25kDa) |
| Pureté | > 90 % (visually by SDS-PAGE) |
| Preservative | None |
| Description | Active His6-rhTG3 is based on the TGM3-allele from clone DKFZp686J0716 (isolated from different tissues), corrected by the insertion of the missing T at Position 435. It is N-terminally fused to a hexahistidine-tag resulting in the encoded N-terminal amino acid sequence MHHHHHHAALGV… . His6-rhTG3 is produced in insect cells and purified by ion metal chelating and ion exchange chromatography to more than 95 % purity. The active Form is obtained by treatment with Dispase I. Active His6-rhTG3 is a Ca2+-dependent enzyme. |
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