ERK1 + ERK2 antibody

Extracellular signal-regulated kinase 1 & Extracellular signal-regulated kinase 2, ERK-1 & ERK-2,
Mitogen-activated protein kinase 3 & Mitogen-activated protein kinase 1
Gene name: MAPK3 & MAPK1, PRKM1, PRKM2, PRKM3
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Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors.
More Information
ID Covalab pab75690
Product type Primary antibodies
Clonality Polyclonal antibody
Raised in Rabbit
Immunogen Synthetic peptide, corresponding to Erk1 MAP kinase with the CGG spacer group added and the peptide coupled to KLH.
Activity cross reaction Reacts with human ERK1 and ERK2. Cross reacts with chicken, drosophila, xenopus, bovine, mouse, rat and sheep protein.
Species Bov, Chick, D. mel., Hu, Ma, Xe
Labelling None
Form Antiserum
Storage instructions Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
Target ERK1 + ERK2
Uniprot ID P27361, P28482
Applications FC, ICC, IHC - P, WB
Working dilutions Optimal dilutions should be determined by the end user.
The following are guidelines only:
IHC-P (1:100), WB (1:5000)
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