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ERK1 + ERK2 antibody
Extracellular signal-regulated kinase 1 & Extracellular signal-regulated kinase 2, ERK-1 & ERK-2,
Mitogen-activated protein kinase 3 & Mitogen-activated protein kinase 1
Gene name: MAPK3 & MAPK1, PRKM1, PRKM2, PRKM3
Mitogen-activated protein kinase 3 & Mitogen-activated protein kinase 1
Gene name: MAPK3 & MAPK1, PRKM1, PRKM2, PRKM3
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00038392
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors.
| ID Covalab | pab75690 |
|---|---|
| Product type | Primary antibodies |
| Clonality | Polyclonal antibody |
| Raised in | Rabbit |
| Immunogen | Synthetic peptide, corresponding to Erk1 MAP kinase with the CGG spacer group added and the peptide coupled to KLH. |
| Activity cross reaction | Reacts with human ERK1 and ERK2. Cross reacts with chicken, drosophila, xenopus, bovine, mouse, rat and sheep protein. |
| Species | Bov, Chick, D. mel., Hu, Ma, Xe |
| Labelling | None |
| Form | Antiserum |
| Storage instructions | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. |
| Target | ERK1 + ERK2 |
| Uniprot ID | P27361, P28482 |
| Applications | FC, ICC, IHC - P, WB |
| Working dilutions | Optimal dilutions should be determined by the end user. The following are guidelines only: IHC-P (1:100), WB (1:5000) |
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