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Tumor Necrosis Factors Superfamily
TNF-related products from Covalab
LIGANDS :
RECEPTORS :
Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) and its receptor TWEAKR (Fn14) are mainly expressed by monocytes, dendritic cells and natural killer cells. Their associated cascade signalling pathway is involved in multiple tissue-specific diseases such as retina, liver and kidney, both in mouse and human.
Lower soluble TWEAK (sTWEAK) concentrations have been independently associated with the presence of non-alcoholic fatty liver disease. Studies have demonstrated that a reduction of serum circulating sTWEAK concentrations are associated with the presence of liver steatosis, for administration of sTWEAK reduces fat accumulation in human hepatocytes.