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Tumor Necrosis Factors Superfamily
TNF-related products from Covalab
LIGANDS :
RECEPTORS :
LTβ (LTa1b2) binds to the LTβ-receptor (LTβR), which activates two different NF-κB pathways that lead to distinct patterns of gene induction: the classical NF-κB (RelA/p50) pathway regulates proinflammatory genes expression, while another pathway implying the formation of RelB/p52 complexes activates genes involved in lymphoid organ formation and lymphocyte survival. LIGHT (CD258) also binds to LTβR and activates NF-κB, which stimulates the proliferation of T cells and inhibits growth of the adenocarcinoma HT-29 cells.
In addition, this ligand binds to decoy receptor 3 (DcR3) and herpes virus entry mediator (HVEM) (CD270). HVEM can act as a molecular switch that modulates T cell activation by transducing either positive signals from LIGHT, or inhibitory signals through another of its ligands, B and T lymphocyte associated (BTLA) (CD272), an Ig domain superfamily member.