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Tumor Necrosis Factors Superfamily
TNF-related products from Covalab
LIGANDS :
RECEPTORS :
CD27 plays a key role in several immunological pathways such as T-cell differentiation into effector cells, B cell activation and immunoglobulins synthesis. CD27-deficiency leads to poor immunity against Epstein-Barr virus and is occasionally fatal. CD27 ligand (CD70) is expressed by highly activated lymphocytes while not by normal lymphocytes, and could be a possible target for the treatment of hematopoietic tumors.