PI3K-Akt-mTOR pathway

Akt signalling in cancer

 

Incoming signals

AKT1(pSer473)

Anti-AKT1 IHC staining of human skeletal muscle. Immunohistochemistry of formalin-fixed paraffinembedded tissue after heat-induced antigen retrieval.

Anti-MTOR IHC staining of human testis. Immunohistochemistry of formalin-fixed, paraffinembedded tissue after heat-induced antigen retrieval.

Anti-14-3-3 Beta ICC staining (in green) of HeLa cells. Immunocytochemistry of paraformalhehydefixed cells. DAPI in blue.

Anti-14-3-3 Gamma western blot staining of lane 1 : HeLa cell lysate lane 2 & 3 : bengamide treated (8h) cell lysate.

Anti-AKT1 IHC staining of human skeletal muscle. Immunohistochemistry of formalin-fixed paraffinembedded tissue after heat-induced antigen retrieval.

Anti-BCL2L11/Bim IHC staining of human heart. Immunohistochemistry of formalinfixed, paraffin-embedded tissue after heatinduced antigen retrieval.

Anti-Cyclin D1 IF staining (in green) of HeLa cells. Actin filaments in red.

Anti-EIF4EBP1/4EBP1 IHC staining of human prostate. Immunohistochemistry of formalin-fixed paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-FOXO1 western blot staining of HeLa cell lysate.

Anti-MTOR IHC staining of human testis. Immunohistochemistry of formalin-fixed, paraffinembedded tissue after heat-induced antigen retrieval.

Anti-PDK1 western blot staining of lysate from: lane 1: MWM cell, lane 2: HeLa cell, lane 3: rat brain, lane 4: mouse brain, lane 5: Vero cell, lane 6: ESK-4 cell, lane 7: RK-13 cell, lane 8: MDCK cell.

Anti-PDK1 western blot staining of human heart lysate.

Anti-RPTOR IHC staining of human kidney. Immunohistochemistry of formalin-fixed, paraffinembedded tissue after heat-induced antigen retrieval.

Anti-TSC1 IHC staining of human heart. Immunohistochemistry of formalin-fixed, paraffinembedded tissue after heat-induced antigen retrieval.

Anti-VPS34 western blot staining of HepG2 cell lysate.

Anti-YAP1 homolog staining of HeLa cells expressing YAP1.