Close Forward an order
By clicking this button, you can send a message to your purchasing manager to ask her/him to order this product. All information needed about our company and the product will be automatically attached. You will also have the opportunity to ask us for more information about the product. If so, your request will be forwarded to our technical service.

Captcha

* Required Fields

Back to products list

XRCC5 / Ku80 (Internal) antibody

X-ray repair cross-complementing protein 5
86 kDa subunit of Ku antigen
ATP-dependent DNA helicase 2 subunit 2
ATP-dependent DNA helicase II 80 kDa subunit
CTC box-binding factor 85 kDa subunit (CTC85) (CTCBF)
DNA repair protein XRCC5
Ku80
Ku86
Lupus Ku autoantigen protein p86
Nuclear factor IV
Thyroid-lupus autoantigen (TLAA)
X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
XRCC5, 86 kd subunit, FLJ39089, KARP-1, KARP1, KUB2, NFIV
Single stranded DNA-dependent ATP-dependent helicase. Has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. Binding to DNA may be mediated by XRCC6. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The XRCC5/6 dimer acts as regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold. The XRCC5/6 dimer is probably involved in stabilizing broken DNA ends and bringing them together. The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step. In association with NAA15, the XRCC5/6 dimer binds to the osteocalcin promoter and activates osteocalcin expression. The XRCC5/6 dimer probably also acts as a 5'-deoxyribose-5-phosphate lyase (5'-dRP lyase), by catalyzing the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site near double-strand breaks. XRCC5 probably acts as the catalytic subunit of 5'-dRP activity, and allows to 'clean' the termini of abasic sites, a class of nucleotide damage commonly associated with strand breaks, before such broken ends can be joined. The XRCC5/6 dimer together with APEX1 acts as a negative regulator of transcription.

If you want to order offline

orders@covalab.com - tel: +33 (0) 437 654 230 - fax: +33 (0) 437 289 416

€360.00
Available
Ref : 00020123

* Required Fields

Product Code pab72446
Immunogen Synthetic peptide C-SLAKKDEKTDTLED from an internal region of human XRCC5 / Ku80 (NP_066964.1). Percent identity with other species by BLAST analysis: Human (100%), Gorilla (100%), Orangutan (100%), Gibbon (100%), Monkey (100%), Marmoset (93%).
Target Specificity Reacts with human XRCC5 / Ku80.
Name XRCC5 / Ku80
Uniprot ID P13010
Print datasheet
Product type Primary antibodies
Clonality Polyclonal antibody
Produced in Goat
Species Human
Labelling None
Appearance Liquid
Form Antigen affinity purified
Constituents TBS, pH 7.3, BSA 0.5%
Preservatives NaN3 0.02%
Storage Store at -20°C. Minimize freezing and thawing.
Applications Western Blot, IHC - Paraffin sections, ELISA
Working dilutions Optimal dilution should be determined by the end user.
The following are guidelines only:
ELISA (1:16000)
IHC-P (2.5 µg/ml)
WB (0.1 - 0.3 µg/ml)
Research areas Cell cycle,Immunology
Print datasheet

IHC - XRCC5 / Ku80 (Internal) antibody<br/>(pab72446)<br/>Anti-XRCC5 / Ku80 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 µg/ml.

Newsletter Receive news, promotions and offers in your e-mail box