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p53 antibody (BP53-12)

Cellular tumor antigen p53
Antigen NY-CO-13
Phosphoprotein p53
Tumor suppressor p53
Gene name: TP53, P53
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription

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Ref : 00026713

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Product Code mab70600
Clone BP53-12
Immunogen Recombinant human p53.
Target Specificity Reacts with human TP53 / p53. Hybridoma: Produced by the fusion between BALB/c mouse splenocytes and mouse myeloma P3-X63/AG8.653 cells using conventional hybridoma technology.
Name p53
Uniprot ID P04637
Gene ID 7157
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Product type Primary antibodies
Clonality Monoclonal antibody
Isotype IgG2a / Kappa
Produced in Mouse
Species Human
Labelling None
Appearance Liquid
Conc. / Activity 1 mg/ml
Form Purified (protein A)
Constituents 0.02 M potassium phosphate, 0.5 M NaCl, pH 7.2
Preservatives 0.01% NaN3
Storage +4°C or -20°C, Avoid repeated freezing and thawing.
Applications Western Blot, IHC - Paraffin sections, Immunofluorescence, Immunocytochemistry, ELISA, Immunoprecipitation
Working dilutions Optimal dilution should be determined by the end user.
The following are guidelines only :
ELISA (1:2000 - 1:10000), IHC - P (2.5 µg/ml), IP, WB (1:500 - 1:2000)
Research areas Apoptosis,Autophagy,Cancer,Cell cycle
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IHC : p53 antibody (BP53-12)<br/>(mab70600)<br/>Anti-p53 antibody IHC staining of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody mab70600 concentration 5 ug/ml.

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