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p53 (Acetyl-Lys379) antibody

Cellular tumor antigen p53
Antigen NY-CO-13
Phosphoprotein p53
Tumor suppressor p53
Gene name: TP53, P53
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription.

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€360.00
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Ref : 00023146

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Product Code pab73997
Immunogen Synthetic peptide from human p53 around the acetylated site of Lys379.
Target Specificity Reacts with human TP53 / p53 (Acetyl-Lys379). Cross reacts with mouse and rat protein.
Name p53 Acetyl-Lys379
Uniprot ID P04637
Gene ID 7157
Print datasheet
Product type Primary antibodies
Clonality Polyclonal antibody
Isotype IgG
Produced in Rabbit
Species Human, Mouse, Rat
Labelling None
Appearance Liquid
Conc. / Activity 1 mg/ml
Form Antigen affinity purified
Constituents PBS (without Mg2+, Ca2+), pH 7.4, NaCl 150 mM, glycerol 50%
Preservatives NaN3 0.02%
Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
Applications IHC - Paraffin sections, Immunofluorescence, Immunocytochemistry, ELISA
Working dilutions Optimal dilution should be determined by the end user.
The following are guidelines only :
ELISA (1:10000), IF (1:100 - 1:500), IHC-P (5 µg/ml)
Positive control HeLa cells
Research areas Apoptosis,Autophagy,Cancer,Cell cycle
Print datasheet

IHC : p53 (Acetyl-Lys379) antibody<br/>(pab73997)<br/>Anti-p53 Ac-Lys379 antibody IHC staining of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody pab73997 concentration

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