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Sirtuin 6 (SIRT6) antibody

NAD-dependent protein deacetylase sirtuin-6
Regulatory protein SIR2 homolog 6
SIR2-like protein 6
Gene name: SIRT6, SIR2L6
SIRT6 (SIR2-like protein 6) is a member of the yeast silent information regulator 2 (SIR2) family and possesses both strong ADP-ribosyltransferase activity as well as protein deacetylase activity which is dependent on NAD(+). SIRT6 exerts deacetylase activity towards histone H3K9Ac and H3K56Ac, and alters histone H3 acetylation in telomeric chromatin during cell cycle's S-phase. It deacetylates histone H3K9Ac at NFkB target promoters and downregulates a subset of NFkB target genes. Upon DNA damage, SIRT6 promotes DNA end resection via deacetylation of RBBP8. SIRT6 also serves as a corepressor of the transcription factor HIF1 alpha for regulating the expression of multiple glycolytic genes to control glucose homeostasis, and is required for normal IGF1 serum levels. SIRT6 play critical roles in maintaining telomere integrity, fine-tuning aging-associated gene expression programs, preventing genomic instability, and maintaining metabolic homeostasis, thus impacting on several pathways relevant for cancer, metabolism, aging, cellular senescence and apoptosis.

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Product Code pab50218
Immunogen Synthetic peptide made to an internal region of the human SIRT6 protein (within residues 250-350)
Target Specificity Reacts with human SIRT6. Not tested in other species. The immunogen used for the production of this antibody shows 78% homology with the mouse protein and 71% homology with the rat protein.
Name Sirtuin 6 (SIRT6)
Uniprot ID Q8N6T7
Print datasheet
Product type Primary antibodies
Clonality Polyclonal antibody
Produced in Rabbit
Species Human
Labelling None
Appearance Liquid
Conc. / Activity 1 mg/ml
Form Purified
Constituents Tris-citrate, phosphate, (pH 7-8) buffer
Preservatives NaN3 0.1%
Storage Store at 4°C. Do not freeze.
Applications Western Blot
Working dilutions Optimal dilution should be determined by the end user.
The following are guidelines only:
- WB : 0.5 to 2 µg/ml
Research areas Cancer,Chromatin,Nuclear signaling
Print datasheet

Sirtuin 6 (SIRT6) antibody

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