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Seleno-Glutathione Peroxidase 4 (GPx-4) antibody

Phospholipid hydroperoxide glutathione peroxidase, mitochondrial (PHGPx)
Glutathione peroxidase 4 (GPx-4) (GSHPx-4)
Gene name : GPX4
otects cells against membrane lipid peroxidation and cell death. Required for normal sperm development and male fertility. Could play a major role in protecting mammals from the toxicity of ingested lipid hydroperoxides. Essential for embryonic development. Protects from radiation and oxidative damage.
ongs to the glutathione peroxidase family.

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Product Code pab0196
Immunogen Synthetic peptide derived from N terminal domain of Seleno-glutathione peroxidases (GPx-4)
Target Specificity Reacts with human Seleno-glutathione peroxidases (GPx-4). Cross reacts with mouse and rat proteins.
Name Seleno-Glutathione Peroxidase 4 (GPx-4)
Uniprot ID P36969
Print datasheet
Product type Primary antibodies
Clonality Polyclonal antibody
Produced in Rabbit
Species Human
Labelling None
Appearance Lyophilized powder
Form Antiserum
Preservatives None
Recommendations Must be reconstituted in distilled water.
Storage Lyophilized powder stable for a minimum of 2 years at -20°C.
Store reconstituted antibodies at +4°C.
For extended periods store in aliquots at -20°C.
Antibodies are guaranteed for 6 month from date of receipt.
Applications Western Blot, Immunohistochemistry, Flow Cytometry, ELISA
Working dilutions Optimal dilution should be determined by the end user.
The following are guidelines only :
- FC : 1/100
- IHC : 1/100 to 1/1 000
- WB : 1/200
Research areas Developmental biology,Signal transduction
Print datasheet
- Januel C, El Hentati FZ, Carreras M, Arthur JR, Calzada C, Lagarde M, Véricel E. Phospholipid-hydroperoxide glutathione peroxidase (GPx-4) localization in resting platelets, and compartmental change during platelet activation. Biochim Biophys Acta. 2006 Oct;1761(10):1228-34.
- Véricel E, Januel C, Carreras M, Moulin P, Lagarde M. Diabetic patients without vascular complications display enhanced basal platelet activation and decreased antioxidant status. Diabetes. 2004 Apr;53(4):1046-51.
- Ran Q, Liang H, Gu M, Qi W, Walter CA, Roberts LJ 2nd, Herman B, Richardson A, Van Remmen H. Transgenic mice overexpressing glutathione peroxidase 4 are protected against oxidative stress-induced apoptosis. J Biol Chem. 2004 Dec 31;279(53):55137-46.

Seleno-Glutathione Peroxidase 4 (GPx-4) antibody

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