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Securin antibody

Esp1-associated protein
Pituitary tumor-transforming gene 1 protein (Tumor-transforming protein 1) (hPTTG)
Gene Name : PTTG1, EAP1, PTTG, TUTR1
Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its function is however not limited to a blocking activity, since it is required to activate ESPL1. Negatively regulates the transcriptional activity and related apoptosis activity of TP53. The negative regulation of TP53 may explain the strong transforming capability of the protein when it is overexpressed. May also play a role in DNA repair via its interaction with Ku, possibly by connecting DNA damage-response pathways with sister chromatid separation.

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Product Code pab0756-P
Immunogen Synthetic peptide derived from internal domain of the human Securin
Target Specificity Reacts with human 22 kDa securin. May cross react with mouse and other species due to sequence homology.
Name Securin
Uniprot ID O95997
Print datasheet
Product type Primary antibodies
Clonality Polyclonal antibody
Produced in Rabbit
Species Human, Mouse
Labelling None
Appearance Lyophilized powder
Form Purified (protein A)
Constituents Tris 0,1M, glycine 0,1M, sucrose 2%
Preservatives None
Recommendations Must be reconstituted in distilled water.
Storage Lyophilized powder stable for a minimum of 2 years at -20°C.
Store reconstituted antibodies at +4°C.
For extended periods store in aliquots at -20°C.
Antibodies are guaranteed for 6 month from date of receipt.
Applications Western Blot, Immunohistochemistry, ELISA
Working dilutions Optimal dilution should be determined by the end user.
The following are guidelines only:
- WB : 1/200 to 1/1000
- IHC: 1/50 to 1/200
Research areas Cancer,Cell biology,Cell cycle,Nuclear signaling
Print datasheet

Securin antibody

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