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Saposin-B / Proactivator polypeptide (PSAP) antibody

Saposin-B-Val
Cerebroside sulfate activator (CSAct)
Dispersin
Sphingolipid activator protein 1 (SAP-1)
Sulfatide/GM1 activator
Gene name: PSAP, GLBA, SAP1
The lysosomal degradation of sphingolipids takes place by the sequential action of specific hydrolases. Some of these enzymes require specific low-molecular mass, non-enzymic proteins: the sphingolipids activator proteins (coproteins).
Saposin-A and saposin-C stimulate the hydrolysis of glucosylceramide by beta-glucosylceramidase and galactosylceramide by beta-galactosylceramidase. Saposin-C apparently acts by combining with the enzyme and acidic lipid to form an activated complex, rather than by solubilizing the substrate.
Saposin-B stimulates the hydrolysis of galacto-cerebroside sulfate by arylsulfatase A, GM1 gangliosides by beta-galactosidase and globotriaosylceramide by alpha-galactosidase A. Saposin-B forms a solubilizing complex with the substrates of the sphingolipid hydrolases.
Saposin-D is a specific sphingomyelin phosphodiesterase activator.

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Product Code pab0553
Immunogen Synthetic peptide derived from an internal domain of human PSAP
Target Specificity Reacts with human Saposin-B. May cross react with proteins from other species due to sequence homology
Name Proactivator polypeptide domain Saposin-B (PSAP)
Uniprot ID P07602
Gene ID 5660
Print datasheet
Product type Primary antibodies
Clonality Polyclonal antibody
Produced in Rabbit
Species Human
Labelling None
Appearance Lyophilized powder
Form Antiserum
Preservatives None
Recommendations Must be reconstituted in distilled water.
Storage Lyophilized powder stable for a minimum of 2 years at -20°C.
Store reconstituted antibodies at +4°C.
For extended periods store in aliquots at -20°C.
Antibodies are guaranteed for 6 month from date of receipt.
Applications Western Blot, Immunocytochemistry, ELISA
Working dilutions Optimal dilution should be determined by the end user.
The following are guidelines only :
ICC 1:200 - 1:1 000
WB 1:500 - 1:5 000
Research areas Cell biology,Synthesis and degradation
Print datasheet

Saposin-B / Proactivator polypeptide (PSAP) antibody

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