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Retinal-specific ATP-binding cassette transporter antibody

Retinal-specific ATP-binding cassette transporter
ATP-binding cassette sub-family A member 4
RIM ABC transporter (RIM protein) (RmP)
Stargardt disease protein
Gene name : ABCA4, ABCR
Defects in ABCA4 are the cause of Stargardt disease type 1 (STGD1) .
In the visual cycle, acts as an inward-directed retinoid flipase, retinoid substrates imported by ABCA4 from the extracellular or intradiscal (rod) membrane surfaces to the cytoplasmic membrane surface are all-trans-retinaldehyde (ATR) and N-retinyl-phosphatidyl-ethanolamine (NR-PE). Once transported to the cytoplasmic surface, ATR is reduced to vitamin A by trans-retinol dehydrogenase (tRDH) and then transferred to the retinal pigment epithelium (RPE) where it is converted to 11-cis-retinal. May play a role in photoresponse, removing ATR/NR-PE from the extracellular photoreceptor surfaces during bleach recovery.

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Product Code pab0887-P
Immunogen Synthetic peptide derived from internal domain of human ABCA4 protein.
Target Specificity Reacts with human ABCA4 protein.
Name Retinal-specific ATP-binding cassette transporter
Uniprot ID P78363
Print datasheet
Product type Primary antibodies
Clonality Polyclonal antibody
Produced in Rabbit
Species Human
Labelling None
Appearance Lyophilized powder
Conc. / Activity 1 mg/mL
Form Purified (protein A)
Constituents Tris 0,1M, glycine 0,1M, sucrose 2%
Preservatives None
Recommendations Must be reconstituted in distilled water.
Storage Lyophilized powder stable for a minimum of 2 years at -20°C.
Store reconstituted antibodies at +4°C.
For extended periods store in aliquots at -20°C.
Antibodies are guaranteed for 6 month from date of receipt.
Applications Western Blot, Immunohistochemistry, ELISA
Working dilutions Optimal dilutions should be determined by the end user.
The following are guidelines only :
- WB : 1 to 5 µg/ml
- IHC : 1/100 to 1/1000
Research areas Cell metabolism,Disease-related biomarkers,Signal transduction
Print datasheet

Retinal-specific ATP-binding cassette transporter antibody

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