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Rad9 antibody

Cell cycle checkpoint control protein RAD9A (hRAD9)
DNA repair exonuclease rad9 homolog A
Gene name: RAD9A
Rad9 (cell cycle checkpoint control protein RAD9A or hRAD9) is an evolutionarily conserved protein which serves multiple functions for preserving genomic integrity, and besides its role as intra-S/G2 checkpoint , it also implicates in homologous recombination repair, base excision repair and mismatch repair pathways. PRKCD mediated Rad9 phosphorylation is essential for the assembly of 9-1-1 cell-cycle checkpoint response complex which is recruited to DNA lesion upon damage by RFC (RAD17-replication factor C) clamp loader complex. Thereafter, Rad9 acts as sliding clamp platform on DNA for multiple proteins involved in LP-BER (long-patch base excision repair). 9-1-1 complex stimulates DNA polymerase beta activity/stability, and is necessary for the recruitment of RHNO1 to sites of DNA-DSBs that occurs during S phase of cell cycle. Moreover, Rad9 exerts 3'->5' double stranded DNA exonuclease activity, and it transactivate p53 target genes such as p21 and has been shown to induce apoptosis through its interaction with Bcl-2/Bcl-xL.

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Product Code pab50095
Immunogen Fusion protein of full length human RAD9 protein
Target Specificity Reacts with human RAD9. Not tested in other species.
Name RAD9
Uniprot ID Q99638
Print datasheet
Product type Primary antibodies
Clonality Polyclonal antibody
Produced in Rabbit
Species Human
Labelling None
Appearance Liquid
Form Antigen affinity purified
Preservatives NaN3 0.1%
Storage Short term storage at +4°C.
For extended periods store in aliquots at -20°C.
Antibodies are guaranteed for 6 month from date of receipt.
Applications Western Blot, Immunofluorescence, Immunocytochemistry
Working dilutions Optimal dilution should be determined by the end user.
The following are guidelines only:
- ICC/IF : 1/500
- WB : 1/100
Research areas Cell cycle,Nuclear signaling
Print datasheet

Rad9 antibody

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