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Protein timeless homolog (hTIM) antibody

Gene name : TIMELESS, TIM, TIM1, TIMELESS1
Required for normal progression of S-phase. Involved in the circadian rhythm autoregulatory loop. Negatively regulates CLOCK-NPAS2/BMAL1-induced transactivation of PER1 possibly via translocation of PER1 into the nucleus. Promotes TIPIN nuclear localiZation. Involved in cell survival after DNA damage or replication stress. May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light. May also play an important role in epithelial cell morphogenesis and formation of branching tubules.

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Price From: €158.00
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Product Code pab0643
Immunogen Synthetic peptide derived from Nter domain of human hTIM protein
Target Specificity Reacts with human 138 kDa protein.
Cross reacts with proteins from mouse, rat and other species.
Name Protein timeless homolog (hTIM)
Uniprot ID Q9UNS1
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Product type Primary antibodies
Clonality Polyclonal antibody
Produced in Rabbit
Species Human
Labelling None
Appearance Lyophilized powder
Form Antiserum
Preservatives None
Recommendations Must be reconstituted in distilled water.
Storage Lyophilized powder stable for a minimum of 2 years at -20°C.
Store reconstituted antibodies at +4°C.
For extended periods store in aliquots at -20°C.
Antibodies are guaranteed for 6 month from date of receipt.
Applications Western Blot, Immunohistochemistry, ELISA
Working dilutions Optimal dilution should be determined by the end user.
The following are guidelines only :
- IHC : 1/50 to 1/200
- WB : 1/100 to 1/1 000
Research areas Cancer,Neurology
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Protein timeless homolog (hTIM) antibody

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