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PINK1 antibody

Serine/threonine-protein kinase PINK1, mitochondrial
PTEN-induced putative kinase protein 1
Gene name: PINK1
PTEN induced putative kinase 1 (Pink1) was first discovered when researching the PTEN signaling pathway, thus Pink1 is also involved in many human cancers.It is found in the mitochondria and its homozygous C-terminus mutation has been implicated in the early development of Parkinson's disease. It protects against mitochondrial dysfunction during cellular stress, potentially by phosphorylating mitochondrial proteins. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy). Targets PARK2 to dysfunctional depolarized mitochondria through the phosphorylation of MFN2.

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Product Code pab50992
Immunogen Synthetic peptide made residues 258-274 (YRKSKRGPKQLAPHPNI) of human PINK1.
Target Specificity Reacts with human PINK1.
Name PINK1
Uniprot ID Q9BXM7
Gene ID 65018
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Product type Primary antibodies
Clonality Polyclonal antibody
Produced in Rabbit
Species Human
Labelling None
Appearance Liquid
Conc. / Activity 1 mg/ml
Form Antigen affinity purified
Constituents PBS
Preservatives NaN3 0.02%
Storage Short term storage at +4°C.
For extended periods store in aliquots at -20°C.
Antibodies are guaranteed for 6 month from date of receipt.
Applications Western Blot
Working dilutions Optimal dilution should be determined by the end user.
The following are guidelines only :
WB 1:100-1:2000
Research areas Autophagy,Cancer,Cell death,Disease-related biomarkers,Kinases and phosphatases,Signal transduction
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WB : PINK1 antibody<br/>(pab50992)<br/>Anti-PINK1 antibody WB staining of C-terminally V5His-tagged human PINK1 or N-teminally myc-tagged human PINK1 expressed in HEK293T cells. Antibody pab50992 dilution 1:1000.

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