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Phospholipase C-zeta-1 (PLC-zeta-1) antibody

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1
Phosphoinositide phospholipase C-zeta-1
Phospholipase C-zeta-1 (PLC-zeta-1)
Testis-development protein NYD-SP27
Gene name: PLCZ1
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca2+-dependent manner. Triggers intracellular Ca2+ oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg-activating soluble sperm factor that is transferred from the sperm into the egg cytoplasm following gamete membrane fusion.

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Price From: €202.00
Ref : 00014412

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Product Code pab0367
Immunogen Synthetic peptide derived from internal part of PLC-zeta-1
Target Specificity Reacts with human PLC zeta protein.
No cross reaction
Name Phospholipase C zeta isoform (PLC-zeta-1)
Uniprot ID Q86YW0
Gene ID 89869
Print datasheet
Product type Primary antibodies
Clonality Polyclonal antibody
Produced in Rabbit
Species Human
Labelling None
Appearance Lyophilized powder
Form Antiserum
Constituents Tris 0,1M, glycine 0,1M, sucrose 2%
Preservatives None
Recommendations Must be reconstituted in distilled water.
Storage Lyophilized powder stable for a minimum of 2 years at -20°C.
Store reconstituted antibodies at +4°C.
For extended periods store in aliquots at -20°C.
Antibodies are guaranteed for 6 month from date of receipt.
Applications Western Blot, Immunohistochemistry, Immunocytochemistry, ELISA
Working dilutions Optimal dilution should be determined by the end user.
The following are guidelines only:
WB (1:100 - 1:1000)
ICC (1:50 - 1:1000)
Research areas Lipidomics,Signal transduction
Print datasheet
* Kamali-Dolat Abadi M et al. Cell J. 2016 Fall;18(3):438-45. (WB, Hu)
* Ferrer-Vaquer A et al. J Assist Reprod Genet. 2016 Jun,33(6):747-56. (WB)
* Aarabi M et al. Fertil Steril. 2014 Aug;102(2):440-7.
* Kashir J et al. Fertil Steril. 2013 Jan,99(1):107-17. (ICC, Hu)
* Aarabi M et al. PLoS One. 2012,7(3):e33496. (IHC, ICC / Ms, Hu)
* Kashir J et al. Reprod Biomed Online. 2011 Aug,23(2):263-7. (ICC, Hu)
* Young C et al. Fertil Steril. 2009 May,91(5 Suppl):2230-42.
* Grasa P et al. Hum Reprod. 2008 Nov,23(11):2513-22. (WB)

ICC -  Phospholipase C-zeta-1 (PLC-zeta-1) antibody<br/>(pab0367)<br/>Anti-PLC-zeta-1 antibody ICC staining of human sperm.

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