chemical modifications for peptide synthesis

After synthesis has occurred, peptides can undergo chemical modifications in order to either mimic natural post-translational modification or be used in specific applications (e.g. protein structure or function analysis). If you don't find the modification you are looking for, feel free to contact us for more informations.

Radioisotope labelled residues

¹⁵N Ala
¹⁵N Arg
¹⁵N Asp
¹⁵N Gln
¹⁵N Glu

¹⁵N Gly
¹⁵N Ile
¹⁵N Leu
¹⁵N Lys
¹⁵N Phe

¹⁵N Pro
¹⁵N Thr
¹⁵N Tyr
¹⁵N Val
Others (please contact us)

Fatty acid addition (N-terminus)

Hexanoic acid C₆
Octanoic acid C₈
Decanoic acid C₁₀
Lauric acid C₁₂

Myristic acid C₁₄
Palmitic acid C₁₆
Stearic acid C₁₈
Perfluoro Octanoic acid F₁₅C₈

Perfluoro Decanoic acid F₁₉C₁₀
Perfluoro Lauric acid F₂₃C₁₂
Perfluoro Myristic acid F₂₇C₁₄

Functional group addition (N-terminus)

(H-) Free amino group
3-Mercaptopropyl
9-Fluorenylmethyloxycarbonyl
Acetyl
Acryl
Allyl

Allyloxycarbonyl
Benzoyl (BZ)
Benzyloxycarbonyl (CBZ)
Bromoacetyl
Formyl
Hydroxyphenylpropionic acid

Lipoic acid
Maleimide, Maleoyl-β-Ala
Methotrexate
Pyroglutamyl
Succinyl
Tertbutoxycarbonyl (Boc)

Functional group addition (C-terminus)

(OH-) Free carboxylic acid group
7-amino-4-methylcoumarin
Alcohol (-OH)
Aldehyde (-CHO)
Amide
Chloromethylketone

Cysteamide
Fluoromethylketone
Hydroxysuccinimide ester
p-Nitroaniline
Para-nitrophenol
Methyl ester

Ethyl ester
Benzyl ester
Tertiobutyl ester
Tertiobenzyl ester
Methylamin
Ethylamin

Phosphorylation

pSer
pThr
pTyr
D-pSer

D-pThr
D-pTyr
2-sites in sequence
3-sites in sequence

4-sites in sequence
5-sites in sequence

Atom linker

2 atoms (Gly)
3 atoms (β-Ala)
4 atoms (GABA)

5 atoms (Ava)
6 atoms (Ahx)
9 atoms (Mini-PEG, AEEA)

13 atoms (Mini-PEG2, AEEEP)
16 atoms (Mini-PEG3, AEEEEP)

Fluorescence / Dye labelling (N-terminus)

3-Indolylacetic acid
5-FAM
5-FAM (via side chain of Lys)
5-FAM-LC
Biotin
Biotin (via side chain of Lys)
Biotin-LC

Cys (Npys)
D-Luciferin
Dansyl
Dansyl (via side chain of Lys)
Dansyl-LC
FITC
FITC (via side chain of Lys)

FITC-LC
MCA
PyBA-, 1-pyrenebutyric acid
TMR
TMR (via side chain of Lys)

Fluorescence / Dye labelling (Internal)

5-FAM (via side chain of Lys)
Biotin (via side chain of Lys)
Dab (Dnp)

Dansyl (via side chain of Lys)
Dap (Dnp), Dpa
Dnp (via side chain of D-Lys)

Dnp (via side chain of Lys)
FITC (via side chain of Lys)
TMR (via side chain of Lys)

Fluorescence / Dye labelling (C-terminus)

5-FAM (via side chain of Lys)
Biotin (via side chain of Lys)
Dab (Dnp)
Dansyl (via side chain of Lys)

Dap (Dnp), Dpa
Dnp (via side chain of D-Lys)
EDBiotin
EDDnp

FITC (via side chain of Lys)
TMR (via side chain of Lys)

Quenched fluorescent peptide

Abz / Tyr (3-NO₂)
Abz

DABCYL
DABCYL / Glu (EDANS)-NH₂

Glu (EDANS)-NH₂
Tyr (3-NO₂)

MAPS and Carrier Complex

Asymmetric 2 branches (Pure)
Asymmetric 4 branches (Crude)
Asymmetric 8 branches (Crude)
n-mer branch peptide on Lys side chain
n-mer branch peptide on Ser side chain
n-mer branch peptide on Thr side chain

Alkine (via side chain of Lys)
Glu 2 branches (Pure)
Glycerol 3 branches
Maleimide (via side chain of Lys)
Methylmalonyl (via side chain of Lys)
MTX (via side chain of Lys)

Pal (via side chain of Lys)
Suc (via side chain of Lys)
BSA-Peptide
KLH-Peptide
OVA-Peptide

Cyclisation

Cyclisation via amide group (end)
Cyclisation via amide group (side chain)
Cyclisation via thioester group

Disulfide bond (simple)
Disulfide bond (double)
Disulfide bond (triple)

Inter-Disulfide bond (Same Sequence)
Inter-Disulfide bond (Different)

◁ Back to Peptide Synthesis page