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PARK7 / DJ-1 (C-Terminus) antibody

Protein DJ-1
Oncogene DJ1
Parkinson disease protein 7
Gene name: PARK7
Protects cells against oxidative stress and cell death. Plays a role in regulating expression or stability of the mitochondrial uncoupling proteins SLC25A14 and SLC25A27 in dopaminergic neurons of the substantia nigra pars compacta and attenuates the oxidative stress induced by calcium entry into the neurons via L-type channels during pacemaking. Eliminates hydrogen peroxide and protects cells against hydrogen peroxide-induced cell death. May act as an atypical peroxiredoxin-like peroxidase that scavenges hydrogen peroxide. Following removal of a C-terminal peptide, displays protease activity and enhanced cytoprotective action against oxidative stress-induced apoptosis. Stabilizes NFE2L2 by preventing its association with KEAP1 and its subsequent ubiquitination. Binds to OTUD7B and inhibits its deubiquitinating activity.

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€360.00
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Ref : 00021427

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Product Code pab73154
Immunogen Synthetic peptide C-AAQVKAPLVLKD from the C-terminus of human PARK7 / DJ-1 (NP_001116849.1; NP_009193.2). Percent identity with other species by BLAST analysis: Human (100%), Gorilla (100%), Gibbon (100%), Monkey (100%), Marmoset (100%), Mouse (92%)
Target Specificity Reacts with the C-terminus part of human PARK7 / DJ-1. Variants (NP_001116849.1; NP_009193.2) encode the same protein.
Name PARK7 / DJ-1
Uniprot ID Q99497
Gene ID 11315
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Product type Primary antibodies
Clonality Polyclonal antibody
Produced in Goat
Species Human, Monkey
Labelling None
Appearance Liquid
Conc. / Activity 0.5 mg/ml
Form Antigen affinity purified
Constituents TBS, pH 7.3, BSA 0.5%
Preservatives NaN3 0.02%
Storage Store at -20°C. Minimize freezing and thawing.
Applications Western Blot, IHC - Paraffin sections, ELISA
Working dilutions Optimal dilution should be determined by the end user.
The following are guidelines only :
ELISA (1:32000), IHC-P (3.75 µg/ml), WB (0.5 - 1 µg/ml)
Research areas Autophagy,Cancer,Disease-related biomarkers,Inflammation,Neurology
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IHC : PARK7 / DJ-1 (C-Terminus) antibody<br/>(pab73154)<br/>Anti-PARK7 / DJ-1 antibody IHC staining of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody pab73154 concentration 3

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