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Park7 / DJ-1 antibody

Protein DJ-1
Oncogene DJ1
Parkinson disease protein 7
Gene name: PARK7
Park7/DJ-1 is one of several genes thought to cause autosomal-recessive early-onset parkinsonism. Protects cells against oxidative stress and cell death. Plays a role in regulating expression or stability of the mitochondrial uncoupling proteins SLC25A14 and SLC25A27 in dopaminergic neurons of the substantia nigra pars compacta and attenuates the oxidative stress induced by calcium entry into the neurons via L-type channels during pacemaking. Eliminates hydrogen peroxide and protects cells against hydrogen peroxide-induced cell death.

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Ref : 00036088

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Product Code pab50920
Immunogen A synthetic peptide mapping to the human PARK7 (DJ-1) protein, residues 167-189. AIVEALNGKEVAAQVKAPLVLKD
Target Specificity Reacts with human, rat and mouse (brain) PARK7. Predicted to react with monkey based on 100% sequence homology. Immunogen has 86% homology to chicken and pig.
Name Park7 / DJ-1
Uniprot ID Q99497
Gene ID 11315
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Product type Primary antibodies
Clonality Polyclonal antibody
Produced in Rabbit
Species Human, Mouse, Rat
Labelling None
Appearance Liquid
Conc. / Activity 1.0 mg/ml
Form Antigen affinity purified
Constituents PBS
Preservatives NaN3 0.02%
Storage Short term storage at +4°C.
For extended periods store in aliquots at -20°C.
Antibodies are guaranteed for 6 month from date of receipt.
Applications Western Blot, Immunohistochemistry, IHC - Paraffin sections, Immunofluorescence, Immunocytochemistry
Working dilutions Optimal dilution should be determined by the end user.
The following are guidelines only:
ICC/ IF 1:100 - 1:500,
IHC 1:1000,
IHC-P 1:1000,
WB 1:500-1:1000
Research areas Autophagy,Cancer,Disease-related biomarkers,Inflammation,Neurology
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IHC : Park7 / DJ-1 antibody<br/>(pab50920)<br/>Anti-Park7 antibody IHC staining of reactive human astrocytes in Pick's disease.

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