Close Forward an order
By clicking this button, you can send a message to your purchasing manager to ask her/him to order this product. All information needed about our company and the product will be automatically attached. You will also have the opportunity to ask us for more information about the product. If so, your request will be forwarded to our technical service.

Captcha

* Required Fields

Back to products list

p53 antibody (H53C2)

Cellular tumor antigen p53
Antigen NY-CO-13
Phosphoprotein p53
Tumor suppressor p53
Gene name: TP53, P53
Belongs to the p53 family.
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription.

If you want to order offline

orders@covalab.com - tel: +33 (0) 437 654 230 - fax: +33 (0) 437 289 416

Price From: €158.00
Available
Ref : 00012795

* Required Fields

Product Code mab0052-P
Clone H53C2
Immunogen Recombinant 6-histidine-troncated p53(6H-Cp53)
Target Specificity Reacts with human truncated p53 from MCF7 cells and endogenous p53 from various tumour cells.
Name Cellular tumor antigen p53
Uniprot ID P04637
Gene ID 7157
Print datasheet
Product type Primary antibodies
Clonality Monoclonal antibody
Isotype IgG1 / Kappa
Produced in Mouse
Species Human
Labelling None
Appearance Lyophilized powder
Conc. / Activity 1 mg/ml
Form Purified (protein A)
Constituents Tris 0,1M, glycine 0,1M, sucrose 2%
Preservatives None
Recommendations Must be reconstituted in distilled water.
Storage Lyophilized powder stable for a minimum of 2 years at -20°C.
Store reconstituted antibodies at +4°C.
For extended periods store in aliquots at -20°C.
Antibodies are guaranteed for 6 month from date of receipt.
Applications Western Blot, Immunohistochemistry, ELISA, Immunoprecipitation
Working dilutions Optimal dilution should be determined by the end user.
The following are guidelines only :
IHC (1:100 - 1:500)
IP (1:50 - 1:200)
WB (1:200 - 1:1000)
Research areas Apoptosis,Autophagy,Cancer,Cell cycle
Print datasheet
* Voeltzel T. et al. A new set of monoclonal antibodies directed to proline-rich and central regions of p53.Hybrid Hybridomics. 2004 Oct:23(5):287-92.

p53 antibody (H53C2)

Newsletter Receive news, promotions and offers in your e-mail box