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Otoferlin antibody (13A9)

Otoferlin
Fer-1-like protein 2
Gene name : OTOF, FER1L2
Otoferlin is a key presynaptic SNARE protein involved in the control of neurotranmitter release and in the fusion of synaptic vesicle with the neuonal plasma membrane. Expressed in the synapses of cochlear inner hair cells

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Product Code mab0053-P
Clone 13A9
Immunogen GST-fusion protein (fragment 1-395)
Target Specificity Reacts with human, mouse and rat Otoferlin.
Name Otoferlin
Uniprot ID Q9HC10
Gene ID 9381
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Product type Primary antibodies
Clonality Monoclonal antibody
Isotype IgG1 / Kappa
Produced in Mouse
Species Human, Mouse, Rat
Labelling None
Appearance Lyophilized powder
Conc. / Activity 1 mg/ml
Form Purified (protein A)
Constituents Tris 0,1M, glycine 0,1M, sucrose 2%
Preservatives None
Recommendations Must be reconstituted in distilled water.
Storage Lyophilized powder stable for a minimum of 2 years at -20°C.
Store reconstituted antibodies at +4°C.
For extended periods store in aliquots at -20°C.
Antibodies are guaranteed for 6 month from date of receipt.
Applications Western Blot, Immunohistochemistry, Immunofluorescence, Flow Cytometry, ELISA, Immunoprecipitation
Working dilutions Optimal dilution should be determined by the end user.
The following are guidelines only :
IHC (1:100 - 1:500)
IP (1:50 - 1:200)
WB (1:200 - 1:1000)
Research areas Cell biology,Neurology,Vesicle trafficking
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* Roux et al. Otoferlin, defective in a human deafness form, is essential for exocytosis at the auditory ribbon synapse. Cell. 2006 Oct 20:127(2):277-89.
* Rouillon I. et al. Results of cochlear implantation in two children with mutations in the OTOF gene. Int J Pediatr Otorhinolaryngol. 2006 Apr:70(4):689-96.

IF - Otoferlin antibody (13A9)<br/>(mab0053-P)<br/>Anti-Otoferlin antibody IF staining of mouse inner ear tissue. Otoferlin is detected in the hair cells of the crista ampullaris (CA) , utricular macula (UM) and saccularmacula (SM).

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