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Nurr1 antibody

transcriptionally inducible nuclear receptor related 1
T-cell nuclear receptor NOT
Transcriptionally-inducible nuclear receptor
orphan nuclear receptor NR4A2
Orphan nuclear receptor NURR1
human homolog of nuclear receptor subfamily 4, group A, member 2
Gene name: NR4A2
The Nurr1 gene encodes a member of the steroid-thyroid hormone- retinoid receptor superfamily. The encoded protein may act as a transcription factor. Mutations in this gene have been associated with disorders related to dopaminergic dysfunction, including Parkinson's. Nurr1 is a stem cell marker and cooperates with PITX3 to promote terminal maturation of murine and human embryonic stem cell cultures to a midbrain dopamine neuron phenotype.In addition, Nurr1 is involved in the regulation of corticotropin-releasing hormone (CRH), which may be linked to and associated with rheumatoid arthritis.

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€335.00
Available
Ref : 00036429

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Product Code pab51098
Immunogen Synthetic peptide comprising residues 513-526 [TERHGLKEPKRVEE] of the human Nurr1 protein.Based on 100% sequence homology, this antibody is also expected to cross react with rat and mouse Nurr1.
Target Specificity Reacts with human and rat Nurr1
Name Nurr1
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Product type Primary antibodies
Clonality Polyclonal antibody
Isotype IgG
Produced in Rabbit
Species Human, Rat
Labelling None
Appearance Liquid
Form Antigen affinity purified
Constituents PBS
Preservatives NaN3 0.02%
Storage Short term storage at +4°C.
For extended periods store in aliquots at -20°C.
Antibodies are guaranteed for 6 month from date of receipt.
Applications Western Blot, Immunohistochemistry
Working dilutions Optimal dilution should be determined by the end user.
The following are guidelines only :
- IHC : 1/100 to 1/200
- WB : 1/1000 to 1/2000
Research areas Immunology,Inflammation,Neurology,Stem cells
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Nurr1 antibody

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