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Nijmegen breakage syndrome 1 (NBS1) antibody

Nibrin
Cell cycle regulatory protein p95
Nijmegen breakage syndrome protein 1
Gene name: NBN, NBS, NBS1, P95
The p95 gene (identical to NBS1 and nibrin) is a member of the hMre11/hRad50 double-strand break complex.This protein complex has been implicated in Nijmegen breakage syndrome, an autosomal recessive disorder marked by increased cancer incidence, cell cycle checkpoint deficits, and ionizing radiation sensitivity, thus revealing a direct molecular link between double-strand break repair and cell cycle checkpoint functions.

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Product Code pab50002
Immunogen Partial length human NBS1 protein [Swiss-Prot# O60934].
Target Specificity Reacts with NBS1 from human, mouse, hamster and primate.
Name Nijmegen breakage syndrome 1 (NBS1)
Uniprot ID O60934
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Product type Primary antibodies
Clonality Polyclonal antibody
Produced in Rabbit
Species Human, Mouse, Hamster, Monkey
Labelling None
Appearance Liquid
Form Antiserum
Preservatives NaN3 0.02%
Storage Aliquot and store at -20°C or -80°C. Avoid freeze-thaw cycles.
Applications Western Blot, Immunofluorescence, Immunocytochemistry, Immunoprecipitation
Working dilutions Optimal dilution should be determined by the end user.
The following are guidelines only :
- ICC : 1/50 to 1/200
- IF : 1/200
- IP : 3 µl
- WB : 1/1000
Research areas Cancer,Chromatin
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ICC/IF : Nijmegen breakage syndrome 1 (NBS1) antibody<br/>(pab50002)<br/>Anti-NBS1 antibody ICC staining of HeLa cells.

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