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NEDD4-like E3 ubiquitin-protein ligase WWP1 antibody

Atrophin-1-interacting protein 5 (AIP5)
TGIF-interacting ubiquitin ligase 1 (Tiul1)
WW domain-containing protein 1
Gene name : WWP1
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates ERBB4 isoforms JM-A CYT-1 and JM-B CYT-1, KLF2, KLF5 and TP63 and promotes their proteasomal degradation. Ubiquitinates RNF11 without targeting it for degradation. Ubiquitinates and promotes degradation of TGFBR1; the ubiquitination is enhanced by SMAD7. Ubiquitinates SMAD6 and SMAD7. Ubiquitinates and promotes degradation of SMAD2 in response to TGF-beta signaling, which requires interaction with TGIF

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Product Code pab0879-P
Immunogen Synthetic peptide derived from internal part of human WWP1 protein
Target Specificity Reacts with human WWP1 protein.
Name NEDD4-like E3 ubiquitin-protein ligase WWP1
Uniprot ID Q9H0M0
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Product type Primary antibodies
Clonality Polyclonal antibody
Produced in Rabbit
Species Human
Labelling None
Appearance Lyophilized powder
Conc. / Activity 1 mg/ml
Form Purified (protein A)
Constituents Tris 0,1M, glycine 0,1M, sucrose 2%
Preservatives None
Recommendations Must be reconstituted in distilled water.
Storage Lyophilized powder stable for a minimum of 2 years at -20°C.
Store reconstituted antibodies at +4°C.
For extended periods store in aliquots at -20°C.
Antibodies are guaranteed for 6 month from date of receipt.
Applications Western Blot, ELISA
Working dilutions Optimal dilutions should be determined by the end user.
The following are guidelines only :
WB (1:200 - 1:2000)
Research areas Signal transduction,Synthesis and degradation,Virology
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* Zaarour RF et al. Ezrin ubiquitylation by the E3 ubiquitin ligase, WWP1, and consequent regulation of hepatocyte growth factor receptor activity. PLoS One. 2012,7(5):e37490.

NEDD4-like E3 ubiquitin-protein ligase WWP1 antibody

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