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mTOR (aa2440-2457) antibody

Serine/threonine-protein kinase mTOR
FK506-binding protein 12-rapamycin complex-associated protein 1
FKBP12-rapamycin complex-associated protein
Mammalian target of rapamycin (mTOR)
Mechanistic target of rapamycin
Rapamycin and FKBP12 target 1
Rapamycin target protein 1
Gene name; MTOR, FRAP, FRAP1, FRAP2, RAFT1, RAPT1
Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. MTOR directly or indirectly regulates the phosphorylation of at least 800 proteins. Functions as part of 2 structurally and functionally distinct signaling complexes mTORC1 and mTORC2 (mTOR complex 1 and 2). Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. This includes phosphorylation of EIF4EBP1 and release of its inhibition toward the elongation initiation factor 4E (eiF4E).

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€360.00
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Ref : 00015170

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Product Code pab70158
Immunogen Synthetic peptide from human mTOR (aa2440-2457).
Target Specificity Reacts with of human mTOR. cross react with mouse and rat
Name MTOR
Uniprot ID P42345
Gene ID 2475
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Product type Primary antibodies
Clonality Polyclonal antibody
Produced in Rabbit
Species Human, Mouse, Rat
Labelling None
Appearance Liquid
Conc. / Activity 0.4 mg/ml
Form Antigen affinity purified
Constituents K phosphate 20 mM, NaCl 150 mM, pH 7.2
Preservatives NaN3 0.01%
Storage +4°C or -20°C, Avoid repeated freezing and thawing.
Applications Western Blot, IHC - Paraffin sections, Immunofluorescence, ELISA
Working dilutions Optimal dilution should be determined by the end user.
The following are guidelines only :
ELISA (1/4000 - 1/20000),
IHC - P (2.5 µg/ml),
WB (1/250 - 1/2000)
Research areas Autophagy,Cancer,Cell metabolism,Kinases and phosphatases,PI3K | AKT | mTOR,Post translational modifications
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IHC : MTOR (aa2440-2457) antibody<br/>(pab70158)<br/>Anti-MTOR antibody IHC staining of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody pab70158 concentration 5 µg/ml.

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