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Metabotropic Glutamate Receptor 1a antibody

Gene name: GRM1
The Metabotropic Glutamate Receptor mGluR1 binds L-glutamate, the major excitatory neurotransmitter in the central nervous system, which activates both ionotropic and metabotropic glutamate receptors.Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. mGluR1 and mGluR5 are group I receptors that have been shown to activate phospholipase C.Alternative splice variants of the mGluR1 gene have been described, but their full-length nature has not been determined.Inflammation results in the activation of mGluR1 and mGluR5 in dorsal horn neurons of the spinal cord, leading to extracellular signal-regulated kinase (ERK) activation, which is required for nociceptive plasticity and enhanced pain.mGluR1 has been reported in various regions of the brain and spinal cord.ESTs have been isolated from brain and eye libraries.Caution:GLUR1 refers to Ionotropic Glutamate Receptor 1, not to Metabotropic Glutamate Receptor 1 (mGLUR1).

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€335.00
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Ref : 00036336

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Product Code pab51033
Immunogen Synthetic peptide derived from internal domain of the human GluR1 alpha protein. Reacts with rat and mouse GluR1.
Target Specificity Reacts with GluR1 from human, mouse and rat.
Name metabotropic Glutamate Receptor 1a
Print datasheet
Product type Primary antibodies
Clonality Polyclonal antibody
Isotype IgG
Produced in Rabbit
Species Human, Mouse, Rat
Labelling None
Appearance Liquid
Form Antigen affinity purified
Constituents PBS
Preservatives NaN3 0.02%
Storage Short term storage at +4°C.
For extended periods store in aliquots at -20°C.
Antibodies are guaranteed for 6 month from date of receipt.
Applications Western Blot, Immunohistochemistry
Working dilutions Optimal dilution should be determined by the end user.
The following are guidelines only :
- IHC : 1/100 to 1/500
- WB : 1/500 to 1/1000
Print datasheet

Metabotropic Glutamate Receptor 1a antibody

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